HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-5-chloro-2-methoxybenzoic acid → tert-Butyl (3-{[(4-amino-5-chloro-2-methoxyphenyl)carbonyl](methyl)amino}propyl)methylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-5-chloro-2-methoxybenzoic acid | HCID 81626 | — |
| Reactant | tert-butyl N-methyl-N-(3-(methylamino)propyl)carbamate | HCID 17868293 | — |
| Product | tert-Butyl (3-{[(4-amino-5-chloro-2-methoxyphenyl)carbonyl](methyl)amino}propyl)methylcarbamate | HCID 86663478 | 68.4% |
Reaction Steps
4-Amino-5-chloro-2-methoxybenzoic acid (500 mg, 2.48 mmol) and tert-butyl methyl[3-(methylamino)propyl]carbamate (652 mg, 3.22 mmol) were used to give the title compound (655 mg; yield, 68%) as a colorless oily substance according to the method described in Example 12a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476253B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-447434d1fa3f443f8a556975f88c5fac |
| Source note | uspto-grants-2013_07 |