HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl chloroformate → Morphine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 131710346 | HCID 131710346 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Morphine | HCID 5288826 | — |
Reaction Steps
O3 -Carboxymethyl morphine (3.43 g) and 1.31 ml isobutyl chloroformate were combined in 30 ml DMF at 0°. The resulting clear solution was then added to a stirring solution of 2.88 g BSA and 13 g NaHCO3 in 600 ml of water at 0°. Addition was carried out by means of a syringe with its tip below the solution surface. The solution was stirred in a cold room overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04174384 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-e97ed492edc14387bce9f58b66b21d96 |
| Source note | uspto-grants-1979_11 |