HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5,7-Dichloro-4-naphthalene-2-yl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3,5-Dichloroaniline | HCID 12281 | — |
| Reactant | 2-Vinylnaphthalene | HCID 13230 | — |
| Reactant | 2-Ketobutyrate | HCID 3593277 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5,7-Dichloro-4-naphthalene-2-yl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester | HCID 10135594 | 84% |
Reaction Steps
Compound 11 was prepared in a yield of 84% by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 2-vinylnaphthalene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699877B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-bffe6a37296f496b8008a9b371b5644d |
| Source note | uspto-grants-2004_03 |