HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 474613Generated: October 24, 2026
4'-Fluoroacetophenone → 1-[4-(4-Chloro-3-trifluoromethylphenoxy)-phenyl]-ethanone
https://huagongshe.com/en/reaction/474613
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)phenol | HCID 80520 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-[4-(4-Chloro-3-trifluoromethylphenoxy)-phenyl]-ethanone | HCID 67775020 | 97.4% |
Reaction Steps
A mixture of 4-chloro-3-(trifluoromethyl)phenol (2 g, 10.18 mmol), 1-(4-fluorophenyl) ethanone (1.406 g) and K2CO3 (2.3 g, 16.64 mmol) in DMF (18 mL) was heated with a microwave condition at 145° C. for 4 h. The solution was diluted with EA and washed with water twice, dried over Na2SO4 and concentrated in vacuo to afford the title compound (3.12 g, 97% yield) as a brown oil. LCMS: rt=3.83 min, [M+H+]=315
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637536B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-d136af2ecdab44e1b33ffca4552371bf |
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| Source note | uspto-grants-2014_01 |
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