HuagongsheHuagongshe Chemistry Print Report · For research reference only
Procainamide → 4-Anilino-5-bromo-2-{4-{N-[2-(diethylamino)ethyl]carbamoyl}anilino}pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Procainamide | HCID 4913 | — |
| Reactant | 5-bromo-2-chloro-N-phenylpyrimidin-4-amine | HCID 11403389 | — |
| Product | 4-Anilino-5-bromo-2-{4-{N-[2-(diethylamino)ethyl]carbamoyl}anilino}pyrimidine | HCID 18768060 | — |
Reaction Steps
Using an analogous method to that described in Example 103, but starting from 4-{N-[2-(diethylamino)ethyl]carbamoyl}aniline and 4-anilino-5-bromo-2-chloropyrimidine (Method 15), the product was obtained. NMR: 1.0 (t, 6H), 2.4 (m, 4H), 3.3 (m, 4H) 7.2 (t, 1H), 7.4 (t, 2H), 7.6 (t, 6H), 8.1 (bs, 1H), 8.2 (s, 1H), 8.7 (s, 1H), 9.6 (s, 1H); MS (MH+): 483, 485.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06649608B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-8dddd4bf727a4144b4cf883792ddd8c9 |
| Source note | uspto-grants-2003_11 |