HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-benzyl-1H-imidazol-2-yl)methanol | HCID 311778 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-benzyl-2-(chloromethyl)-1H-imidazole hydrochloride | HCID 2779243 | — |
Reaction Steps
A solution of 1-benzyl-2-hydroxymethyl-imidazole (6 g, 32 mmol) in methylenechloride is slowly added thionylchloride (3.5 ml, 48 mmol) and after stirring at ambient temperature for 4 hours the reaction mixture is concentrated in vacuo yielding 1-benzyl-2-chloromethyl-imidazole, hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05296493 |
| Source dataset | uspto-grants-1994_03 |
| ORD ID | ord-bcd326844a504e529e1c11e39bf5243e |
| Source note | uspto-grants-1994_03 |