HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500099Generated: October 23, 2026
1,4-Butane sultone → 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole
https://huagongshe.com/en/reaction/500099
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Butane sultone | HCID 15411 | — |
| Reactant | Sulfolane | HCID 31347 | — |
| Reactant | 2,3-Dimethyl-3-(4-sulfobutyl)-3H-indole-5-sulfonic acid | HCID 59366226 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole | HCID 86646192 | 86.8% |
Reaction Steps
To 2,3-dimethyl-3-(4-sulfobutyl)-5-sulfo-3H-indole (10 g) was added butane sultone (30 g) and the mixture heated to 140° C. overnight. On cooling to room temperature, sulfolan (20 ml) was added and the mixture poured into diethyl ether (500 ml). The resultant precipitate was removed by filtration and dried to give the desired product (12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767829B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-967fe06e8ce64cbea94cfa6f6fa5c726 |
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| Source note | uspto-grants-2010_08 |
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