HuagongsheHuagongshe Chemistry Print Report · For research reference only
Kanamycin A Sulfate → (2S,3R,4R,5S,6S)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Kanamycin A Sulfate | HCID 441374 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2S,3R,4R,5S,6S)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol | HCID 11274101 | 113.6% |
Reaction Steps
Kanamycin sulfate (20.0 g) was dissolved in 200 mL of water. This was loaded on a column prepared with 400 g of AMBERLITE IRA-140 resin (6.4 cm×17.5 cm). The column was eluted with water, and the appropriate fractions were collected and lyophilized to give 18.9 g of kanamycin A (free base) (18).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07781570B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-475ee180131f46c7bdd3e9346254273f |
| Source note | uspto-grants-2010_08 |