HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylaldehyde → (Z)-3-(2-aminoethyl)-5-(2-hydroxybenzylidene)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-(2-Aminoethyl)-5-(phenylmethylidene)-1,3-thiazolidine-2,4-dione | HCID 1551244 | — |
| Reactant | 3-(2-(Tritylamino)ethyl)thiazolidine-2,4-dione | HCID 71697168 | — |
| Product | (Z)-3-(2-aminoethyl)-5-(2-hydroxybenzylidene)thiazolidine-2,4-dione | HCID 18532020 | — |
Reaction Steps
The title compound 30i was prepared from 2-hydroxybenzaldehyde (76 mg, 0.62 mmol), compound 29 (250 mg, 0.62 mmol) and piperidine (20.0 μL, 0.19 mmol) in a manner similar to that described for 30a in 50.0% (117 mg) yield as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115122B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b62b2550bf8d4680b5bdab13d3cac635 |
| Source note | uspto-grants-2015_08 |