1-(4-methoxyphenyl)-N-methylmethanamine → 4-(N-(4-methoxybenzyl)-N-methylsulfamoyl)benzoic acid

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Reaction Steps

Prepared as in example 5-27 from 1-(4-methoxyphenyl)-N-methylmethanamine and methyl 4-(chlorosulfonyl)-benzoate (Example 5-10c). MS (M−H, 335.1); 1H NMR (400 MHz, DMSO-d6): δ, ppm: 2.51 (s, 3H), 3.71 (s, 3H), 4.05 (s, 2H), 6.88 (d, 2H), 7.18 (d, 2H), 7.91 (d, 2H); 8.13 (d, 2H). Elemental analysis: (found): C, 57.47%; H, 4.77%; and N, 4.31%. (theoretical): C, 57.30%; H, 5.11%; and N, 4.18%.

Provenance & Evidence