Hydrochloric Acid → 2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid

Participants

Reaction Steps

A mixture of 4-hydrazinobenzoic acid (5.0 g, 32.9 mmol) and cyclohexanone (3.3 g, 33 mmol) in 30 mL of acetic acid was heated under reflux for 4 hours, then cooled, diluted with water and acidified with HCl. The resultant solid was collected by filtration, washed with water and dried to give 3.6 g of the title compound as a crystalline solid.

Provenance & Evidence