HuagongsheHuagongshe Chemistry Print Report · For research reference only
Temozolomide → 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Temozolomide | HCID 5394 | — |
| Reactant | 2,4-Bis(4-phenoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane | HCID 11813414 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide | HCID 3352880 | — |
Reaction Steps
A mixture of temozolomide (3 g, 15.5 mmol) and Belleau's reagent (4.49 g, 8.5 mmol) was refluxed in DCM (80 mL) overnight. The reaction was quenched with water and the precipitate was filtered and washed with diethyl ether to give the pure title compound as an orange solid. (2.75 g, 84%). δH, (DMSO-d6): 9.92 (1H, s), 9.45 (1H, s), 8.81 (1H, s), 3.85 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09024018B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-25cdbd6d9c284c5b9de55719f0c358de |
| Source note | uspto-grants-2015_05 |