HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57549Generated: October 24, 2026
Water → N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine
https://huagongshe.com/en/reaction/57549
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-5-nitropyridine | HCID 78240 | — |
| Reactant | 4-(Methylamino)tetrahydro-2H-pyran | HCID 6991950 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-methyl-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 71113503 | — |
Reaction Steps
To a solution of N-methyltetrahydro-2H-pyran-4-amine (172.5 mg, 1.5 mmol) in CH3CN (5 mL) was added K2CO3 (207 mg, 1.5 mmol) and 2-bromo-5-nitropyridine (203 mg, 1 mmol). The reaction was stirred at 80° C. for 16 hours. TLC and LC-Ms showed the reaction had completed and the reaction was poured into water, extracted with EA, washed with water and brine, dried and concentrated to give a yellow solid. MS (m/z): 238 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434726B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-60fad13e37c44b7d8325cf471ccdbb2f |
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| Source note | uspto-grants-2016_09 |
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