(R)-2-amino-3-methylbutanamide → HCID 178480102, compound

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Reaction Steps

The title compound was prepared in a similar procedure as described in Example (R)-3-((1-amino-3-methyl-1-oxobutan-2-yl)amino)-5-((1-methyl-1H-indol-4-yl)amino)-1,2,4-triazine-6-carboxamide. Here though, 1H-Pyrazole-3-methanamine was utilized instead of (R)-2-amino-3-methylbutanamide. MS found for C17H17N9O as (M+H)+ 364.4. UV: λ=211, 239 nm. Proton NMR: (CD3OD) δ 7.90 (1H, d, J=8.0 Hz), 7.62 (1H, m), 7.34 (1H, d, J=8.8 Hz), 7.28 (1H, d, J=3.2 Hz), 7.20 (1H, t, J=8.0 Hz), 6.63 (1H, d, J=3.6 Hz), 6.33 (1H, m), 4.76 (2H, m), 3.85 (3H, s) ppm.

Provenance & Evidence