HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(3,5-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(3,5-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid | HCID 24689209 | 48% |
Reaction Steps
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 3,5-difluoroaniline (0.575 g; 4.36 mmol) in ethanol (3 mL). 1-(3,5-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 0.167 g (48%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434722B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-6747e784b02f4e8eadb693597e86eadd |
| Source note | uspto-grants-2016_09 |