HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 8-Quinolinecarboxylic acid | HCID 66582 | — |
| Reactant | N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide | HCID 89740834 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide | HCID 89739334 | — |
Reaction Steps
N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide was prepared according general procedure A using quinoline-8-carboxylic acid and N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide which was synthesized from the product from Part VI above, following ketal cleavage using TFA and CH2Cl2. MS (ESI) 464 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440982B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-79d459c41a05423997f37c19c5489e52 |
| Source note | uspto-grants-2016_09 |