HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(Phenylmethyl)thiourea → N-benzyl-4-(pyridin-2-yl)thiazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(Phenylmethyl)thiourea | HCID 737375 | — |
| Reactant | 2-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide | HCID 2776231 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-benzyl-4-(pyridin-2-yl)thiazol-2-amine | HCID 2902584 | — |
Reaction Steps
A solution of 2-(Bromoacetyl)pyridine hydrobromide (100 mg, 0.36 mmol) in ethanol (2 mL) was treated with 1-benzyl-2-thiourea (90 mg, 0.54 mmol). The resulting yellow solution was concentrated, and the crude residue was purified on reverse phase HPLC to produce N-benzyl-4-(pyridin-2-yl)thiazol-2-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321761B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-12ad8a3d918842789af2cb1dad38d843 |
| Source note | uspto-grants-2016_04 |