4-Fluorobenzaldehyde → 4-Fluorobenzoyl chloride

Participants

Reaction Steps

A process for the preparation of 3-chloro-4-fluorobenzoyl chloride, which comprises reacting 4-fluorobenzaldehyde with a chlorinating agent in the presence of a free-radical initiator in the presence or absence of a solvent at from −20 to 200° C. to give 4-fluorobenzoyl chloride, and reacting the 4-fluorobenzoyl chloride with a chlorinating agent in the presence of a chlorination catalyst in the presence or absence of a solvent at from −20 to 200° C. to give 3-chloro-4-fluorobenzoyl chloride.

Provenance & Evidence