HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxymethyl-oxazole → [2-Amino-6-(4-methoxymethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxymethyl-oxazole | HCID 23080903 | — |
| Reactant | (2-Amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester | HCID 86614483 | — |
| Catalyst | Bis(triphenylphosphine)palladium chloride | HCID 84124 | — |
| Product | [2-Amino-6-(4-methoxymethyl-oxazol-2-yl)-3-nitro-pyridin-4-yl]-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester | HCID 67456273 | — |
Reaction Steps
The title compound was prepared following the example in preparation 70, using 4-methoxymethyl-oxazole (110 mg), (2-amino-6-bromo-3-nitro-pyridin-4-yl)-(6-methyl-pyridin-3-ylmethyl)-carbamic acid ethyl ester (200 mg) and palladium bis(triphenylphosphine)dichloride (68 mg), giving the product (107 mg) as a yellow gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07691877B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-9ac59115ac0b469fae32f8dda97f4651 |
| Source note | uspto-grants-2010_04 |