HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Serotonin Hydrochloride | HCID 160436 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,3,4,9-tetrahydro-1H-beta-carbolin-6-ol hydrochloride | HCID 22018498 | — |
Reaction Steps
To a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (10.0 g) in 450 mL of absolute ethanol was added 1.6 g of paraformaldehyde and 5.4 mL of glacial acetic acid. The mixture was heated to reflux for 1.5 h then allowed to cool to rt. The white precipitate so formed was collected by filtration and dried under vacuum to yield 5.9 g of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07084154B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-94519c87f60641e69754c5d68bb615e7 |
| Source note | uspto-grants-2006_08 |