HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-6-bromopicolinic acid → 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Reactant | Tert-butyl (+/-)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine | HCID 86669190 | — |
| Product | 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-yl)picolinamide | HCID 86669192 | — |
Reaction Steps
Following Method 11 of Example 305, tert-butyl (+/−)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine was coupled to 3-amino-6-bromopicolinic acid yielding 3-amino-6-bromo-N-(4-(3-(tert-butyldimethylsilyloxy)-piperidin-1-yl)pyridin-3-yl)picolinamide. LCMS (m/z): 506.2 (MH+); LC Rt=4.03 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-101accd70817478cbf41745f620923f4 |
| Source note | uspto-grants-2014_09 |