HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-tert-butyl dicarbonate → tert-butyl N-[6-chloro-2-(trifluoromethyl)pyrimidin-4-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine | HCID 245271 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | tert-butyl N-[6-chloro-2-(trifluoromethyl)pyrimidin-4-yl]carbamate | HCID 87669774 | — |
Reaction Steps
Method 24 was followed using 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (1.0 equiv.), BOC2O (1.0 equiv.), and DMAP (cat.) to afford tert-butyl 6-chloro-2-(trifluoromethyl)pyrimidin-4-ylcarbamate in 64%. LCMS (m/z): 298.1 (MH+); LC Rt=4.73 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-6afc93268c104228859111cfbfd1091d |
| Source note | uspto-grants-2014_09 |