HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminophenol → 4-amino-5-bromo-N2-(3-hydroxyphenyl)-2-pyrimidineamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 4-Amino-5-bromo-2-chloropyrimidine | HCID 2763293 | — |
| Product | 4-amino-5-bromo-N2-(3-hydroxyphenyl)-2-pyrimidineamine | HCID 22060476 | — |
Reaction Steps
In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-4-pyrimidinediamine, 4-amino-5-bromo-2-chloropyrimidine and 3-aminophenol were reacted to give 4-amino-5-bromo-N2-(3-hydroxyphenyl)-2-pyrimidineamine. 1H NMR (DMSO-d6): δ 10.33 (br s, 1H), 8.27 (s, 1H), 7.14-6.06 (m, 2H), 7.01 (d, 1H, J=1.7 Hz), 6.54 (td, 1H, J=1.7 Hz and 7.0 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822685B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e04ae71c06714024a105d27988a6b46d |
| Source note | uspto-grants-2014_09 |