HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-benzyloxypyridine → 8-Benzyloxy-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-benzyloxypyridine | HCID 90334 | — |
| Reactant | 4-(Bromoacetyl)-5-methyl-3-phenylisoxazole | HCID 2735531 | — |
| Product | 8-Benzyloxy-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine | HCID 24738340 | 50% |
Reaction Steps
As described for Example 2, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-3-benzyloxypyridine instead of 2-amino-3-methylpyridine, to the title compound (96 mg, 50%) which was obtained as a light yellow solid. MS: m/e=382.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07585874B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-62f7fa825a104343a1edb21b492e7b90 |
| Source note | uspto-grants-2009_09 |