HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | Potassium | HCID 5462222 | — |
| Reactant | 3-Azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 10932520 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Tert-butanol tetrahydrofuran | HCID 66775918 | — |
| Product | 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester | HCID 86749790 | — |
Reaction Steps
A solution of 3-azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one [prepared as described by Watthey et al., J. Med. Chem., 28, p. 1511-15156 (1985)] in tetrahydrofuran/tert-butanol was cooled to 0° C. and treated with ethyl acrylate and 1N tert-butanol, potassium salt/tetrahydrofuran according to the procedure of Example 40 part (a) affording 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester as a syrup. TLC (ethyl ether:hexane, 1:1) Rf =0.45.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552397 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-2b23418bfa884de780aa21ac80fc4e8c |
| Source note | uspto-grants-1996_09 |