HCID 178418734, compound → ethyl 2-[(R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-4-[(RS)-1-phenylethoxy]-5-pyrimidinecarboxylate

HRID 7432

Reaction equation

HRID 7432 reaction equation
OC1C(C(OCC)=O)=CN=C(N2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14]2)N=1.[OH:22][C:23]1[C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:27][N:26]=[C:25]([N:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH2:36][C@H:35]2[CH3:43])[N:24]=1>>[CH3:43][C@@H:35]1[CH2:36][C:37]2[C:42](=[CH:41][CH:40]=[CH:39][CH:38]=2)[N:34]1[C:25]1[N:24]=[C:23]([O:22][CH:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH3:14])[C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 178418734HCID 178418734, compoundHCID 178418799HCID 178418799, compound

Product 1

HCID 58680119ethyl 2-[(R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-4-[(RS)-1-phenylethoxy]-5-pyrimidinecarboxylate

Procedure

In the same manner as in Reference Example 3-1 using ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate and ethyl 4-hydroxy-2-[(R)-2-methyl-2,3-dihydro-1H-indol-1-yl]-5-pyrimidinecarboxylate as starting materials, compounds of Reference Examples 26 and 27 were synthesized.

Workup

  1. customwere synthesized

Sources & evidence

ORD record
ord-9d6f264348c148c5921ef355a3645ed6
Source dataset
uspto-grants-2006_08
Patent number
US07087597B1

Linked notes

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