HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Benzenediol, 4-methyl- → 5-(Cyclohexylmethoxy)-2-methylphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Benzenediol, 4-methyl- | HCID 10333 | — |
| Reactant | Cyclohexane, (bromomethyl)- | HCID 137636 | — |
| Product | 5-(Cyclohexylmethoxy)-2-methylphenol | HCID 67316675 | — |
Reaction Steps
Alkylation of 4-methylbenzene-1,3-diol using (bromomethyl)cyclohexane following the method used in Example 154 gave 5-(cyclohexylmethoxy)-2-methylphenol as a light yellow oil. Yield (0.15 g, 8.5%): 1H NMR (400 MHz, CDCl3) δ 6.96 (d, J=8.4 Hz, 1H), 6.36-6.41 (m, 2H), 3.68 (d, J=6.4 Hz, 2H), 2.16 (s, 3H), 1.64-1.89 (m, 6H), 1.14-1.34 (m, 3H), 0.96-1.08 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829244B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9007ca62883f426fa61a1eaa9a09d29c |
| Source note | uspto-grants-2014_09 |