N-benzyloxycarbonyl-beta-benzyl-L-aspartyl-D-alanine → alpha-L-aspartyl-D-alanine-(R)-alpha-methoxymethylbenzylamide

Participants

Reaction Steps

The same process as in Example 15 was repeated, except that N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-alanine was used in place of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine and that (R)-α-methoxymethylbenzylamine hydrochloride was used in place of (R)-α-ethoxymethyl benzylamine hydrochloride, and α-L-aspartyl-D-alanine-(R)-α-methoxymethylbenzylamide was obtained as a solid product. The total yield was 57.3%.

Provenance & Evidence