HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 4-(2-(N-ethylcarbamoyl)-4-pyridyloxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 4-chloropyridine-2-carbonyl Chloride | HCID 11095146 | — |
| Reactant | 4-chloro-N-ethylpyridine-2-carboxamide | HCID 22832131 | — |
| Product | 4-(2-(N-ethylcarbamoyl)-4-pyridyloxy)aniline | HCID 23614559 | — |
Reaction Steps
Entry 88: 4-Chloropyridine-2-carbonyl chloride was reacted with ethylamine according to Method A2, Step 3b. The resulting 4-chloro-N-ethyl-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 to give 4-(2-(N-ethylcarbamoyl)-4-pyridyloxy)aniline. 4-Bromo-3-(trifluoromethyl)aniline was converted into 4-bromo-3-(trifluoromethyl)phenyl isocyanate according to Method B1. According to Method C1a, 4-bromo-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(2-(N-ethylcarbamoyl)-4-pyridyloxy)aniline to afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841330B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ee181981982e4c7e87fd0200ffb8ce34 |
| Source note | uspto-grants-2014_09 |