3,4-Dichlorophenethylamine → [3-Chloro-4-(1-methylcyclopropyl)-benzyl]-[2-(3,4-dichlorophenyl)-ethyl]-amine

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Reaction Steps

The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 3-chloro-4-(1-methylcyclopropyl)-benzaldehyde (prepared as described in example S105) (90 mg, 0.46 mmol), 2-(3,4-dichlorophenyl)-ethylamine (88 mg, 0.46 mmol) and sodium borohydride (26 mg, 0.70 mmol). The desired product (168 mg, 99%) was isolated without further purification as a colorless oil. MS (ISP) 370.1 (M+H)+.

Provenance & Evidence