HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminophenol → Benzenamine, 4-(2-benzoxazolyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 2-Aminothiophenol | HCID 8713 | — |
| Product | Benzenamine, 4-(2-benzoxazolyl)- | HCID 88733 | — |
| Product | 2-(4-Aminophenyl)benzothiazole | HCID 234475 | — |
| Product | 4-(1H-1,3-benzodiazol-2-yl)aniline | HCID 345677 | — |
Reaction Steps
In Scheme 4a, a 2-aminophenol, 2-aminothiophenol or 2-aminoaniline derivative 4a is heated with an appropriately substituted 4-aminobenzoic acid 4b in polyphosphoric acid at about 170° C. to 200° C. for 4–10 hr, preferably 190° C. for 6 hr, to yield the corresponding 4-benzoxazol-2-yl-phenylamine, 4-benzothiazol-2-yl-phenylamine, or 4-benzimidazol-2-yl-phenylamine derivatives 1e4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07262318B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-7d98f82e19554deb993c9bf779e78a0e |
| Source note | uspto-grants-2007_08 |