HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylthiomethyl-3,4,6-trifluoroaniline → 3,4,6-Trifluoro-2-methylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylthiomethyl-3,4,6-trifluoroaniline | HCID 18974461 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,4,6-Trifluoro-2-methylaniline | HCID 22625178 | 71.3% |
Reaction Steps
To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05563138 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-909b848f416c4d2fb54608b479e09d05 |
| Source note | uspto-grants-1996_10 |