HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → 2-[(3-Bromophenyl)methoxy]oxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Triphenylphosphonium bromide | HCID 80811 | — |
| Reactant | 3-Bromobenzyl alcohol | HCID 85141 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[(3-Bromophenyl)methoxy]oxane | HCID 15282064 | — |
Reaction Steps
The alcohol of Step 1 (41.23 mmol), dihydropyran (12.5 mL, 137 mmol) and triphenylphosphine hydrobromide (725 mg, 2.11 mmol) were mixed together in 200 mL of CH2Cl2 and stirred for 2 days. The solvent was then evaporated and the title product was purified by flash chromatography on silica using EtOAc:toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05565473 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-951d072502734c138b4dcecf8cf6d3d9 |
| Source note | uspto-grants-1996_10 |