HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-1,3-dioxaindan-4-amine → HCID 57955619, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-1,3-dioxaindan-4-amine | HCID 2736891 | — |
| Reactant | 2-Chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[4,5-B][1,4]diazepin-6(7H)-one | HCID 57955574 | — |
| Product | HCID 57955619 | HCID 57955619 | — |
Reaction Steps
The title compound was synthesized from 2-chloro-9-cyclopentyl-7,7-difluoro-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one and 2,2-difluorobenzo[d][1,3]dioxol-4-amine using the procedure described in the general Buchwald Reaction Scheme. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.20-1.84 (m, 9H) 3.97 (t, J=14.40 Hz, 2H) 4.50-4.70 (m, 1H) 7.14 (d, J=2.27 Hz, 1H) 7.31 (dd, J=7.45, 2.15 Hz, 1H) 8.21 (s, 1H) 9.39 (s, 1H). [M+H] calculated for C20H19F4N5O3, 454. found 454.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026234B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-71483f93ef4d4c61ab20b813cbb38c90 |
| Source note | uspto-grants-2011_09 |