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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9684Generated: October 24, 2026

2,3,6-Trimethylphenol → {5-[4-(Trifluoromethyl)phenyl]-3-[(2,3,6-trimethylphenoxy)methyl]thien-2-yl}methanol

https://huagongshe.com/en/reaction/9684

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3,6-TrimethylphenolHCID 17016—
ReactantMethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylateHCID 21986302—
Product{5-[4-(Trifluoromethyl)phenyl]-3-[(2,3,6-trimethylphenoxy)methyl]thien-2-yl}methanolHCID 21986293—

Reaction Steps

The title compound was prepared using methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate (intermediate 132) and 2,5,6-trimethylphenol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-2c1878949a1b4ee18a068a524f55b987
Source noteuspto-grants-2006_08