HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxyphthalimide → N-(4-octyloxybenzyloxy)phthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | p-Octyloxybenzyl alcohol | HCID 144261 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-octyloxybenzyloxy)phthalimide | HCID 19969096 | 83.4% |
Reaction Steps
Diethyl azodicarboxylate (18.4 g) was added dropwise to a suspension of 4-octyloxybenzyl alcohol (25 g), N-hydroxyphthalimide (17.15 g) and triphenylphosphine (27.74 g) in tetrahydrofuran (250 ml) under ice-cooling. The reaction mixture was stirred at room temperature for 2 hours, and evaporated in vacuo. The residue was purified by chromatography on silica gel to give N-(4-octyloxybenzyloxy)phthalimide (33.45 g) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USH0001638 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-e527255a53ed4f3889660a581d775414 |
| Source note | uspto-grants-1997_03 |