Sodium Glycerophosphate

HCID 14754CAS 1300-25-0
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基本情報

標準SMILES
O=P([O-])([O-])OCC(O)CO.[Na+].[Na+]
InChIKey
GEKBIENFFVFKRG-UHFFFAOYSA-L
分子式
C3H7Na2O6P
平均分子量
216.04 g/mol
単同位体質量
215.97756313

概要

Sodium glycerophosphate is one of several glycerophosphate salts. It is used clinically to treat or prevent low phosphate levels. Glycerophosphate is hydrolyzed to inorganic phosphate and glycerol in the body. The extent of this reaction is dependent on the activity of serum alkaline phosphatases.

名称と識別子

優先名称
Sodium Glycerophosphate
IUPAC
disodium;2,3-dihydroxypropyl phosphate
英語名
Sodium b-Glycerophosphate Hydrate
分子式
C3H7Na2O6P
分子量
216.037381

名称と別名

SODIUM GLYCEROPHOSPHATESodium glycerophosphate hydrate1,2,3-Propanetriol, mono(dihydrogen phosphate), disodium salt, hydrateRefChem:886696241-577-055073-41-1RCS9EQ01V41555-56-2Sodium 1-glycerophosphate1334-74-3Disodium alpha-glycerophosphatealpha-Glycerophosphoric Acid Disodium Salt
名称をさらに表示
Sodium b-Glycerophosphate Hydrate
disodium;2,3-dihydroxypropyl phosphateSodium 2,3-dihydroxypropyl phosphateDisodium glycerol phosphate1300-25-0disodium 2,3-dihydroxypropyl phosphateSodium glycerophosphate anhydrousdisodium |A-glycerophosphate1,2,3-Propanetriol, 1-(dihydrogen phosphate), disodium salt

データベース識別子

CAS
1300-25-0、1334-74-3、1555-56-2、17603-42-8、55073-41-1
PubChem CID
14754
DTXSID
DTXSID801014666
ChEMBL
CHEMBL6067979
UNII
G43E72677U
EC Number
215-613-0、216-304-3、241-577-0
Nikkaji
J8.671A

物性

構造計算による物性

極性表面積
113 Ų
水素結合供与体数
2
水素結合受容体数
6
回転可能結合数
3
重原子数
12

実験および物理化学的性質

PolymersOther Classes -> Alcohols and Polyols, Other
CosmeticsOral care; Buffering; Antiplaque; Emulsifying
SolubilitySoluble
Human Drugs · 2 件

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physical DescriptionSolid; [Sigma-Aldrich MSDS]

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 100% (54 of 54) of all reports.

Not Classified

Aggregated GHS information provided per 54 reports by companies from 1 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 100% (48 of 48) of all reports.

Not Classified

Aggregated GHS information provided per 48 reports by companies from 1 notifications to the ECHA C&L Inventory.

危険有害性情報

Regulatory Information · 5 件

Chemical: 1,2,3-Propanetriol, 1-(dihydrogen phosphate), disodium salt

Chemical: 1,2,3-Propanetriol, 1-(dihydrogen phosphate), sodium salt

Disodium glycerol phosphate: Does not have an individual approval but may be used under an appropriate group standard

1,2,3-Propanetriol, 1-(dihydrogen phosphate), disodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Sodium glycerophosphate, hydrate: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See Glycerin.
Hazard Classes and Categories · 3 件

Not Classified

Not Classified

Not Classified

化学と産業

薬理情報

ATC Code · 2 件

B - Blood and blood forming organs

QB - Blood and blood forming organs

PharmacodynamicsGlycerophosphate acts as a source of inorganic phosphate through hydrolysis.
Mechanism of ActionSodium glycerophosphate acts as a donor of inorganic phosphate. See [DB09413] for a description of phosphate's role in the body.
Biological Half-LifeInorganic phosphate has a half-life of elimination of 2.06h.
Metabolism/MetabolitesGlycerophosphate is hydrolyzed to form inorganic phosphate. The extent of this reaction is dependent on serum alkaline phosphatase activity.
Absorption, Distribution and Excretion · 2 件

Peak serum phosphate concentration is reached in 4h.

Inorganic phosphate produced is eliminated in the urine. There may be a very small amount of glycerophosphate excreted in the urine unchanged.

用途と製造

Use ClassificationCosmetics -> Oral care; Buffering; Antiplaque; Emulsifying
General Manufacturing Information · 3 件

1,2,3-Propanetriol, mono(dihydrogen phosphate), sodium salt (1:2): ACTIVE

1,2,3-Propanetriol, 1-(dihydrogen phosphate), sodium salt (1:2): ACTIVE

1,2,3-Propanetriol, 1-(dihydrogen phosphate), sodium salt (1:?): ACTIVE

サプライヤー1 社

HONEST JOY HOLDINGS LIMITED[email protected]

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