| GHS 分類 | This chemical does not meet GHS hazard criteria for 32.5% (292 of 898) of reports.WarningH302 (54.9%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 898 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] |
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| 規制情報 | Chemical: Antimony oxide (Sb2O5)Antimony oxide (Sb2O5) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Antimony oxide (Sb2O5) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 20-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/16264Antimony oxide: Does not have an individual approval but may be used under an appropriate group standard |
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| 有害性の概要 | Intraperitoneal LD50 (mouse) = 978 mg/kg[RTECS] Does not fully correspond to Sb2-O5 and is always somewhat hydrated[Merck Index] A skin and strong eye irritant[Sigma-Aldrich MSDS] See Antimony and linked occupational diseases. |
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| Hazard Classes and Categories | Acute Tox. 4 (54.9%)Hazardous to the aquatic environment (Acute) - Category 3 |
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| Threshold Limit Values (TLV) | 0.5 [mg/m3], as Sb |
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| Permissible Exposure Limit (PEL) | 0.5 [mg/m3], as Sb |
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| Immediately Dangerous to Life or Health (IDLH) | 50.0 [mg/m3], as Sb |
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| Treatment | Following oral exposure to antimony, administer charcoal as a slurry (240 mL water/30 g charcoal). Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (T36) |
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| 健康影響 | Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands). Antimony poisoning can also lead to pneumoconiosis. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Increased blood pressure can also result from antimony poisoning. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Cerebral oedema, coma, convulsions, and death are possible. (L741) |
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| 暴露経路 | Inhalation (L741)oral (L741)dermal (L741) |
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| 毒性の概要 | The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. Antimony pentoxide might enhance the rate of heme degradation in liver and kidney. (A240, T18, L741, A238) |
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| Signs and Symptoms | Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (T64, L741) |
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| Carcinogen Classification | No indication of carcinogenicity (not listed by IARC). (L135) |
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| Toxicity Data | LD50: 4000 mg/kg (Oral, Rat) (L790)
LD50: 978 mg/kg (Oral, Mice) (L790) |
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| RAIS Toxicity Values | 0.0005HEAST Current |
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| Hazard Quotient Level 0.1 or Cancer Risk Level 1E-06 | 3.90e+015.80e+029.70e+006.00e+005.00e-04Volatile |
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| Hazard Quotient Level 3 or Cancer Risk Level 1E-04 | 1.20e+021.80e+032.90e+016.00e+005.00e-04Volatile |
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