ラフォキサニド

Rafoxanide

HCID 31475CAS 22662-39-1

基本情報

標準SMILES
O=C(Nc1ccc(Oc2ccc(Cl)cc2)c(Cl)c1)c1cc(I)cc(I)c1O
InChIKey
NEMNPWINWMHUMR-UHFFFAOYSA-N
分子式
C19H11Cl2I2NO3
平均分子量
626 g/mol
単同位体質量
624.82054457

概要

Rafoxanide is a salicylanilide resulting from the formal condensation of the carboxy group of 2-hydroxy-3,5-diiodobenzoic acid with the amino group of 3-chloro-4-(4-chlorophenoxy)aniline. It is a broad-spectrum anthelmintic used for the treatment of parasitic infections in cattle and sheep. It has a role as an autophagy inducer, a chemosensitiser, an antibacterial agent, an anthelminthic drug, an antineoplastic agent, an antifungal agent, a DNA synthesis inhibitor, a B-Raf inhibitor and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a secondary carboxamide, a member of benzamides, a member of phenols, an aromatic ether, an organoiodine compound, a member of salicylanilides and a member of monochlorobenzenes.

名称と識別子

優先名称
Rafoxanide
IUPAC
N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
現地名
ラフォキサニド
英語名
Rafoxanide
分子式
C19H11Cl2I2NO3
分子量
626.01

名称と別名

RAFOXANIDE22662-39-1RafoxanidaRafoxanidumRafoxanid3'-Chloro-4'-(p-chlorophenoxy)-3,5-diiodosalicylanilideDTXSID5046227NSC-35527822F4FLA7DHBenzamide, N-(3-chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodo-DTXCID3026227Benzamide, N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-
名称をさらに表示
フルカニドラホキサニドボバニドズオファスN-[3-クロロ-4-(4-クロロフェノキシ)フェニル]-2-ヒドロキシ-3,5-ジヨードベンズアミド3'-クロロ-4'-(p-クロロフェノキシ)-2-ヒドロキシ-3,5-ジヨードベンズアニリドラニドラフォキサニドラフォキサニド標準品3'-クロロ-4'-(4-クロロフェノキシ)-3,5-ジヨードサリチルアニリド3′-クロロ-4′-(p-クロロフェノキシ)-2-ヒドロキシ-3,5-ジヨードベンズアニリドN-[3-chloro-4-(4-chlorophenoxy)phenyl]-3,5-diiodobenzamidemk-990Rezonit
RefChem:389260245-148-9DisalanRanideFlukanideBovanideDuofasRanide, veterinary

データベース識別子

CAS
22662-39-1
PubChem CID
31475
DTXSID
DTXSID5046227
ChEMBL
CHEMBL287542
ChEBI
CHEBI:234200
UNII
22F4FLA7DH
EC Number
245-148-9
Nikkaji
J11.487A

物性

構造計算による物性

XLogP
7
極性表面積
58.6 Ų
水素結合供与体数
2
水素結合受容体数
3
回転可能結合数
4
重原子数
27

物理化学的性質

融点
168 · 168-170°
沸点
526.6 · 526.6±50.0 °C(Predicted)
比重(密度)
2.05 · 2.050±0.06 g/cm3(Predicted)
貯蔵温度
2 · Keep in dark place,Sealed in dry,2-8°C
溶解性
クロロホルム(微量)、DMSO(微量)、酢酸エチル(微量)
酸解離定数(Pka)
6.04 · 6.04±0.48(Predicted)

化学的性質

化学的特性White to Off-White Solid

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 6.5% (2 of 31) of reports.

Danger

H360D (90.3%): May damage the unborn child [Danger Reproductive toxicity]

P203, P260, P264, P270, P280, P308+P316, P318, P319, P321, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 31 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Other Safety InformationIMAP assessments - Benzamide, N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-: Environment tier I assessment
Hazard Classes and CategoriesRepr. 1B (90.3%)

安全データ

wgk
3
rtecs
VN7870000
hs_code
2924.29.7790
安衛法
57,57-2
ストレージクラス
11 - Combustible Solids

化学と産業

薬理情報

ATC CodeQP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological Classification · 2 件

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.

Agents used to treat cestode, trematode, or other flatworm infestations in man or animals.

応用分野

使用Rafoxanide is a thyroid hormone receptor.

サプライヤー50 社

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
HubeiwidelychemicaltechnologyCo.,Ltd18627774460 · [email protected]

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