ピルジカイニド

Pilsicainide

HCID 4820CAS 88069-67-4

基本情報

標準SMILES: Cc1cccc(C)c1NC(=O)CC12CCCN1CCC2
InChIKey: BCQTVJKBTWGHCX-UHFFFAOYSA-N
分子式: C17H24N2O
平均分子量: 272.4 g/mol
単同位体質量: 272.18886339

概要

Pilsicainide is a secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a secondary carboxamide and an organic heterobicyclic compound.

名称と識別子

優先名称: Pilsicainide
IUPAC: N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide
現地名: ピルジカイニド
英語名: PILSICAINIDE
分子式: C17H24N2O
分子量: 272.39

名称と別名

Pilsicainide88069-67-4PilzicainidePilsicainidaPilsicainidumDTXSID1046639N-(2,6-Dimethylphenyl)-2-(hexahydro-1H-pyrrolizin-7a-yl)acetamideAV0X7V6CSETetrahydro-1H-pyrrolizine-7a(5H)-aceto-2',6'-xylidideDTXCID9026639CHEBI:135127RefChem:174259

名称をさらに表示

N-(2,6-ジメチルフェニル)テトラヒドロ-1H-ピロリザイン-7a(5H)-アセトアミドピルジカイニドピルシカイニドN-(2,6-ジメチルフェニル)-2,3,6,7-テトラヒドロ-1H-ピロリザイン-7a(5H)-アセトアミドN-(2,6-ジメチルフェニル)テトラヒドロ-1H-ピロリザイン-7a(7H)-アセトアミド2',6'-ジメチル-2-(1-アザビシクロ[3.3.0]オクタン-5-イル)アセトアニリドN-(2,6-ジメチルフェニル)-2-(ヘキサヒドロ-1H-ピロリジン-7a-イル)アセトアミド2′,6′-ジメチル-2-(1-アザビシクロ[3.3.0]オクタン-5-イル)アセトアニリド2′,6′-ジメチル-2-(テトラヒドロ-1H-ピロリザイン-7a(5H)-イル)アセトアニリド2′,6′-ジメチル-2-(テトラヒドロ-1H-ピロリジン-7a(5H)-イル)アセトアニリドN-(2,6-ジメチルフェニル)-(ヘキサヒドロ-1H-ピロリザイン-7a-イル)アセトアミドSunrhythmPILSICAININIDEUnii-av0X7V6csePILSICAINIDE USP/EP/BP

Pilsicainide [INN]N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamideN-(2,6-Dimethylphenyl)-2-(tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetamidePilsicainide (INN)NCGC00167454-01SUN-1165Pilsicainida [INN-Spanish]Pilsicainidum [INN-Latin]

データベース識別子

CAS: 88069-67-4
PubChem CID: 4820
DTXSID: DTXSID1046639
ChEMBL: CHEMBL163238
ChEBI: CHEBI:135127
UNII: AV0X7V6CSE
Nikkaji: J355.412K

物性

構造計算による物性

XLogP: 2.7
極性表面積: 32.3 Å²
水素結合供与体数: 1
水素結合受容体数: 2
回転可能結合数: 3
重原子数: 20
形式電荷: 0
複雑度: 348

実験および物理化学的性質

DrugsPharmaceuticals -> Listed in ZINC15

物理化学的性質

貯蔵温度: 2 · Sealed in dry,2-8°C

安全と法規制

毒性情報

Drug Induced Liver Injury · 4 件

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

Pilsicainide

DILI Positive

DOI:10.1016/j.drudis.2019.09.022

安全データ

risk_code: 22
hazard_code: Xn

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.

応用分野

用途ナトリウムチャネル抑制薬（Ⅰc群）抗不整脈薬

上流・下流製品情報

上流原料

サプライヤー19 社

北京华美互利生物化工010-56205725 · [email protected]

Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]

LGM Pharma1-(800)-881-8210 · [email protected]

PT CHEM GROUP LIMITED+86-85511178; +86-85511178 · [email protected]

陕西缔都医药化工有限公司+86-29-87569262 +86-15003564040 · [email protected]