化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Fluoride
ナトリウムフルオリド · ふっ化ソーダ · ふっ化物イオン標準液 · 4W/V% ふっ化ナトリウム溶液 · フッ化ナトリウム ACS REAGENT,≥99% · フッ化ナトリウム PURISS. P.A.,ACS REAGENT,REAG. ISO,REAG. PH. EUR.,≥99% · フッ化ナトリウム PURISS.,MEETS ANALYTICAL SPECIFICATION OF PH. EUR.,BP,USP,98.5-100.5% (CALC. TO THE DRIED SUBSTANCE) · フッ化ナトリウム PURUM P.A.,≥98.0% (F)
識別子と物理属性
| CAS No. | 7681-49-4 |
|---|---|
| 分子式 | FNa |
| 平均分子量 | 41.9882 g/mol |
| 単同位体質量 | 41.9881725 g/mol |
| SMILES | [F-].[Na+] |
| InChIKey | PUZPDOWCWNUUKD-UHFFFAOYSA-M |
| PubChem CID | 5235 |
| ChEMBL | CHEMBL1528 |
| ChEBI | CHEBI:28741 |
| EC No. | 231-667-8 |
| DTXSID | DTXSID2020630 |
| 現地名 | ナトリウムフルオリド |
化学・物理的性質
| 極性表面積 | 0 |
|---|---|
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 1 |
| 回転可能結合数 | 0 |
| 重原子数 | 2 |
| 形式電荷 | 0 |
| 複雑度 | 2 |
| 物質分類 | Other Classes -> Fluorides, InorganicTeratogens |
| 化粧品 | Oral careAntiplaque |
| pH | 7.4 (Freshly prepared saturated soln)7.0-10.0 (25℃, 0.5M in H2O) |
| SpringerMaterials Properties | crystal structure |
| 臭い | Odorless無臭 |
| 味 | SALTY5X10-3 moles/l in water (Taste detection) |
| 食品添加物 | STABILIZER OR THICKENER -> FDA Substance added to food |
| 密度 | 2.79 at 68 °F (USCG, 1999) - Denser than waterwill sink2.782.8 g/cm³2.78 @25 °C1.02 g/mL at 20 °C |
| Color/Form | Colorless, cubic or tetragonal crystalsWhite powder or colorless crystals [Note: Pesticide grade is often dyed blue]. |
| 溶解度 | 10 to 50 mg/mL at 73 °F (NTP, 1992)4g/100mLInsoluble in alcoholSolubility in water 4.0 g/100 ml water at 15 °C. Solubility in water 4.3 g/100 ml water at 25 °C. Solubility in water 5.0 g/100 ml water at 100 °CSolubility in water, g/100ml at 20 °C: 4.04%H2O: 0.5M at20℃、透明、無色4g/100mL(25℃) |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| 融点 | 993 °C (lit.) |
| 沸点 | 1700 °C |
| 蒸気圧 | 1.4 mm Hg ( 0 °C) |
| 屈折率 | 1.336 |
| 引火点 | 1704°C |
| 貯蔵条件 | 2-8°C |
| 外観・状態 | 粉 |
| 色 | ホワイトからオフホワイト |
| 比重 | 2.558 |
| 比熱容量 | Cp(crystal): 1.12 J/(g·K), at 25℃ |
| Merck | 14,8618 |
| 晶系 | 立方 |
| 空间群 | Fm3m |
| 晶格常数 | a/nmb/nmc/nmα/oβ/oγ/oV/nm30.46330.46330.46339090900.09945 |
| 安定性 | 安定。水で加水分解。鉱酸と反応して、毒性の高いフッ化水素を生成します。ガラス容器は避けてください。 |
| 化粧品成分の機能 | 口腔ケア抗プラーク |
| InChI | 1S/FH.Na/h1H/q+1/p-1 |
| InChIKey | PUZPDOWCWNUUKD-UHFFFAOYSA-M |
| SMILES | [F-].[Na+] |
| CAS データベース | 7681-49-4(CAS DataBase Reference) |
| NISTの化学物質情報 | Sodium fluoride(7681-49-4) |
| EPAの化学物質情報 | Sodium fluoride (7681-49-4) |
化学的特性
Sodium fluoride is a white powder or colorless crystals. Often used in a solution. Odorless. Pesticide grade is often dyed blue.
化学性质
ナトリウムフッ化物は非常に反応性が低く多くの化学物質と反応しない安定した化合物ですしかし強酸と反応させると有毒なフッ化水素HFガスを発生させる可能性があるため取り扱いには注意が必要ですまたナトリウムフッ化物はその高い溶解性により水生環境においても迅速に分散する能力を持っています
安全性と法規制
| GHS 分類 | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P316, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 1.8% (11 of 623) of reports.H301 (97.1%): Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| 規制情報 | Chemical: Sodium fluoride (NaF)Sodium fluoride (NaF) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sodium fluoride (NaF) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14274Sodium fluoride: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| その他の安全情報 | IMAP assessments - Sodium fluoride (NaF): Human health tier I assessment |
| 輸送ラベル（DOT） | Poison |
| 火災危険 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| 火災の可能性 | Not combustible. |
| 健康有害性 | Ingestion may cause vomiting, abdominal pain, diarrhea, convulsions, collapse, thirst, disturbed color vision, acute toxic nephritis. (USCG, 1999)Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
| 有害性の概要 | A skin, eye, and respiratory tract irritantMay cause fluorosis[ICSC] The PEL and IDLH apply to sodium fluoride and other inorganic, solid fluorides. [NIOSH] Abnormal liver enzymes have been reported in cases of sodium fluoride toxicity. [HSDB] See FLUORIDES. |
| 輸送番号・ガイド（DOT） | 3415 1541690 154 |
| FDA 要件 | Sodium fluoride is an indirect food additive for use only as a component of adhesives. Limitation: For use only as bonding agent for aluminum foil, stabilizer, or preservative. Total fluoride for all sources not to exceed 1 percent by weight of the finished adhesive.The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed over-the-counter drug products, incl sodium fluoride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. |
| 反応性グループ | Salts, Basic |
| EC 分類 | Symbol: TR: 25-32-36/38S: (1/2)-22-36-45 |
| UN 分類 | UN Hazard Class: 6.1UN Pack Group: III |
| 消火 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water. |
| 応急処置措置 | Fresh air, rest. Half-upright position. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give one or two glasses of water to drink. Refer for medical attention . |
| 漏出応急措置 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| 応急処置 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:General First Aid:(General first aid procedures) |
| 安全保管 | Separated from acids and food and feedstuffs. |
| 暴露管理・個人防護 | · Wear positive pressure self-contained breathing apparatus (SCBA).Biological Exposure Indices (BEI) [ACGIH] - Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift(Repeated measurements recommended.)1.0 [mg/m3], as F, inhalable fraction[German Research Foundation (DFG)] |
| 消火手順 | Extinguish fire using agent suitable for type of surrounding fire (material itself does not burn or burns with difficulty). Use water in flooding quantities as fogCool all affected containers with flooding quantities of waterApply water from as far a distance as possible. /Sodium fluoride solution/If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. |
| 保管条件 | Aqueous solutions of sodium fluoride slowly decompose and become alkaline when stored in glass. Therefore, sodium fluoride solutions should be stored in tight, plastic containers, especially if the pH of the solution is less than 7.5. Sodium fluoride solutions and tablets should be stored at a temperature less than 40 °C, preferably between 15-30 °Cfreezing of the solutions should be avoided. Sodium fluoride is incompatible with calcium and magnesium salts.Store in a cool, dry, well-ventilated location. Separate from acids and alkalies.Sodium fluoride /container/ ... should be colored to help distinguish it from table salt or flour. |
| 清掃方法 | Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material/SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. /Sodium fluoride solution/Environmental considerations-water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH= 7). /Sodium fluoride solution/Shovel into suitable dry container. Control runoff and isolate discharged material for proper disposal. |
| 非火災時の漏出対応 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| 処分方法 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.Group III Containers (both combustible and non-combustible) that previously held organic mercury, lead, cadmium, arsenic, or inorganic pesticides should be triple rinsed, punctured and disposed of in a sanitary landfill. Non-rinsed containers should be encapsulated and buried at a specially designated landfill site. /Organic mercury, lead, cadmium, arsenic, or inorganic pesticides/A suggested disposal method converts the soluble fluoride ions to insoluble calcium fluoride ... a naturally occurring mineral (fluorspar) which can safely be added to a landfill. The method is as follows: add slowly to a large container of water. Stir in slight excess of Na2CO3 /sodium carbonate/. If fluoride is present add Ca(OH)2 /calcium hydroxide/ also. Let stand 24 hr. Decant or siphon into another container and neutralize with 6 m HCl /hydrochloric acid/ before washing down with large cxcess of water. The sludge may be added to landfill. Recommendable methods: Precipitation & landfill.Precipitation & landfill: Industry wastes with a high fluoride concn are treated in two phases. By adding CaO /calcium oxide/, the soluble fluorides are precipitated as CaF2 /calcium fluoride/ until the concn has been reduced to 10 mg/l. The compact sludge is disposed of on special waste dumps. |
| 漏出処分 | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| 相互作用 | ... To examine the efficacy and safety of administration of calcium and magnesium orally and intraperitoneally to treat severe sodium fluoride intoxication ... mice were initially gavaged a lethal dose of sodium fluoride (NaF) or water. Then, mice were treated with water or varying concentrations of calcium chloride (CaCl2) or magnesium sulfate (MgSO4) via intraperitoneal (IP) route or via oral route. Mice were monitored for 24 h, and the time of death was recorded. ... Intraperitoneal injections of large amounts of CaCl2 or MgSO4 were dangerous. All mice gavaged with water and then treated with oral CaCl2 or MgSO4 survived and displayed normal activity during the experiment. The survival rate of mice gavaged with a lethal dose of NaF and then treated with a high dose of oral CaCl2 or MgSO4 was significantly higher than those of using low dose. /The authors concluded that/ oral administration of a high dose of CaCl2 or MgSO4 is a simple, safe, and effective adjunctive method for treating severe oral fluoride poisoning.Sodium fluoride added with or without sodium selenite in deionized water was administered to male mice for 8 weeks. The influences of fluoride on learning-memory behavior were tested on Y-maze, and the ultrastructure of Gray I synaptic interface in the CA3 area hippocampus was quantitatively analyzed by electron microscopy and computer image processing appliance. The main results showed that the learning capability of mice drinking higher concentration of fluoride presented remarkable deterioration. The thickness of post-synaptic density (PSD) was decreased. The width of the synaptic cleft was remarkably increased. It was found that combined administration of fluoride and proper concentration of selenium could decrease the toxic effect of fluoride. There were synergetic toxicities if the concentration of selenium was too high. The results suggested that selenium might antagonize the neurotoxicity of fluoride on behavior and morphology.The aim of the study was to evaluate the effect of tamoxifen and natrium fluoride (NaF) on bone metabolism, biochemical properties and blood lipids levels in ovariectomized rats. The study was performed in Wistar rats divided into 5 subgroups: ovariectomized controls, rats treated with NaF 20 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr+tamoxifen 2 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr plus tamoxifen 4 mg/kg/24 hr, and sham-operated controls. In ovariectomized rats the increase of total cholesterol, low-density lipoproteins cholesterol (LDL-cholesterol) as well as the decrease of bone mineral content, bone mineral density and biomechanical properties was observed. The therapy with NaF increased the level of total cholesterol, LDL-cholesterol, triglycerides, bone mineral density, bone mineral content. In this group the decrease of bone strength and stiffness was observed. The administration of tamoxifen reduced the changes in plasma lipid levels, but did not improve the biomechanical properties of bone tissue.The study was conducted to characterize the action of NaF, which had relaxing property in carbachol precontracted isolated bovine bronchus, on airway responsiveness challenged by acetylcholine receptor agonists in rats and asthmatic humans. Tracheal flow rate and airway resistance were measured in anaesthetized rats. NaF was delivered either before carbachol challenge or together with carbachol. Patients with mild asthma were challenged with methacholine aerosol, and NaF was delivered when FEV1 fell by more than 20%. The results indicated that: (1) in rats NaF significantly inhibited carbachol-induced bronchial constriction when inhaled prior to carbachol challenge as airway resistances in the NaF and NaF+verapamil groups were significantly lower than those in the control group(2) NaF significantly reversed carbachol or methacholine-induced bronchial constriction in asthmatic patients. In conclusion, NaF, delivered in form of aerosol, reduced bronchial responsiveness to carbachol in rats and had a bronchodilating effect on rat and human airways precontracted by inhalation of acetylcholine analogs.For more Interactions (Complete) data for SODIUM FLUORIDE (12 total), please visit the HSDB record page. |
| 標的器官 | Eyes, skin, respiratory system, central nervous system, skeleton, kidneys |
| 生態毒性値 | LC50Species: Chlorella vulgaris (Green algae)Conditions: freshwaterstaticConcentration: 7000 uM for 3 day /total/pH 6.0Concentration: 14000 uM for 15 day /total/pH 6.8Concentration: 20000 uM for 15 day /total/EC50Species: Ceriodaphnia dubia (Water flea)Concentration: 157.9 g/cu m (95% confidence limit: 110 to 225.1 g/cu m) for 24 hr /total/For more Ecotoxicity Values (Complete) data for SODIUM FLUORIDE (30 total), please visit the HSDB record page. |
| 有害作用 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| 暴露経路 | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.inhalation, ingestion, skin and/or eye contact |
| 生態毒性抜粋 | /AQUATIC SPECIES/ Safe concentrations (SCs) and EC50s of fluoride ion (F-) for five species of aquatic insect larvae, Chimarra marginata, Hydropsyche bulbifera, H. exocellata, H. lobata, and H. pellucidula, are estimated from short-term toxicity bioassays using the multifactor probit analysis (MPA) software on sublethal data. The sublethal effect is defined as net larva migration. The 24, 48, 72, and 96-h EC50s (mg F-/L) were 178.06, 63.90, 45.41, and 38.28 for C. marginata90.06, 36.20, 26.71, and 22.95 for H. bulbifera122.64, 42.45, 29.80, and 24.97 for H. exocellata238.50, 76.22, 52.12, and 43.09 for H. lobataand 185.05, 53.74, 35.58, and 28.96 for H. pellucidula. SC values (or 8760-h EC0.01s) were 1.79 for C. marginata, 0.73 for H. bulbifera, 0.56 for H. exocellata, 1.18 for H. lobata, and 0.39 for H. pellucidula. Thus, C. marginata and H. lobata appears to be less sensitive species to fluoride toxicity during short-term and long-term exposures. This difference in sensitivity to fluoride among test species is not dependent upon the body size of net-spinning caddisfly larvaePearson correlation analysis between estimated SCs and larva dry weights was not significant (P>0.05). On the other hand, SCs calculated for test species are lower than those proposed for other freshwater and marine animals. It is concluded that the multifactor probit analysis of sublethal acute toxicity data can be a valuable methodology in environmental toxicology to estimate accurate safe concentrations of chemical compounds for aquatic organisms. /Fluoride//AQUATIC SPECIES/ Fish exposed to poisonous amounts of sodium fluoride become apathetic, lose weight, have periods of violent movement, and wander aimlessly. Finally, there is a loss of equilibrium accompanied by tetany and death. Mucous secretion increases, accompanied by proliferation of mucous producing cells in the respiratory and integumentary epithelium./OTHER TERRESTRIAL SPECIES/ /It was/ demonstrated that untreated earthworms (Lumbricus terrestris) from which gut soil had been removed (depurated) contained only 6% of the amount of fluoride reported in whole worms. Worms kept in soil were exposed to a sodium fluoride concentration of 1000 mg/L for 30 days. The fluoride content of the worms was established either at the end of exposure or following an 8-day starvation period. The fluoride concentration in treated worms with their gut contents washed out was more than 6 times greater than the fluoride concentration of untreated worms. Even after an 8-day starvation period, the concentration in exposed worms was 4 times greater than the concentration in the unexposed worms. The fluoride concentration in the worms was always lower than the concentration in the soil. |
| Signs and Symptoms | Cough. Sore throat.Redness.Redness. Pain.Abdominal pain. Burning sensation. Convulsions. Drowsiness. Cough. Diarrhoea. Sore throat. Vomiting. Unconsciousness.irritation eyes, respiratory systemnausea, abdominal pain, diarrheasalivation, thirst, sweatingstiff spinedermatitiscalcification of ligaments of ribs, pelvis |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=7681-49-4] |
| Medical Surveillance | Fluoride levels in urine should be checked periodically and all workers should be subjected to periodical skeletal X-ray exam particularly of the pelvis. /Fluoride and cmpd/ |
| Natural Pollution Sources | At Lake Magadi Kenya, raw trona is dredged from encrustations on the lake, crushed, washed, and calcined to convert the sodium sesquicarbonate to soda ash. The calcined material is crushed and screened to produce a dense product with ... a characteristically high (1.0%) sodium fluoride content.Because it is so reactive, fluorine rarely, if ever, occurs naturally in the elementary state, existing instead in the ionic form or as a variety of inorgainc and orgainc fluorides. Rocks, soil, water, air, plants, and animals all contain fluoride in widely-varying concentrations. /Fluoride and fluorine/ |
| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ Two adults were able to withstand a dose of 250 mg with minimal illness. One volunteer experienced slight nausea and epigastric distress lasting about 5 hr and salivation, which was intense for 15 to 30 min and stopped in half an houran itching sensation on his hands and feet lasted for about a week. Another volunteer, who took 250 mg of sodium fluoride on an empty stomach, experienced nausea, which appeared in 2 min and in 20 min incr to a max accompanied by greatly incr salivation and some retching but no vomiting. Two hr after the dose, lunch was eaten but was immediately vomited. Slight nausea continued throughout the following day but disappeared on the second day./SIGNS AND SYMPTOMS/ Acute, nonfatal poisoning is characterized by gastroenteritis (sudden nausea and vomiting, abdominal cramps, burning pain, and diarrhea) lasting for 3 to 6 hr and followed by collapse involving stupor and weakness lasting about 36 hr. Tetany may occur as a result of calcium depletion. In fatal poisoning, muscular weakness appears early and is accompanied by a marked fall in blood pressuretremor may be followed by clonic convulsionsdyspnea may be accompanied by a grayish-blue cyanosis. Death from respiratory and cardiac arrest may occur a few min to 10 hr or more after ingestion but usually in 3 or 4 hr./SIGNS AND SYMPTOMS/ In case of poisoning, plasma calcium may be decr and there is generally a disruption of fluid balance as a result of vomiting. Albuminuria is common ... In acute fatal poisoning there is corrosion of the stomach and sometimes other parts of the gastrointestinal tract. Frequently there is edema of the brain and lungs and petechial hemorrhages of the lungs and heart./SIGNS AND SYMPTOMS/ severe acute fluoride overdose can cause hypocalcemia and tetany and bone pain, especially in the feet and ankles, of uncertain causeelectrolyte disturbances and cardiac arrhythmias have been reported, progressing to cardiac failure or respiratory arrest in some cases.For more Human Toxicity Excerpts (Complete) data for SODIUM FLUORIDE (18 total), please visit the HSDB record page. |
| Artificial Pollution Sources | FROM FACTORIES, PROCESSING FLUORINE CONTAINING ORES, DUSTS MAY CONSIST OF SODIUM FLUORIDE VOLATILIZED .../AND/... THEN CONDENSED BY COOLER SURROUNDING AIR. LEAVES OF PLANTS MAY COLLECT SOME OF THE DUST. EXTENT OF CONTAMINATION WILL DEPEND UPON TOPOGRAPHY OF SURROUNDING TERRAIN & ESPECIALLY DIRECTION OF PREVAILING WIND. |
| FIFRA 要件 | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Sodium fluoride is found on List C. Case No: 3132Pesticide type: insecticide, fungicideCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.Active ingredient (AI): sodium fluorideData Call-in (DCI) Date(s): 9/30/1992AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.. |
| CERCLA 報告数量 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| 清浄水法要件 | Sodium fluoride is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| State Drinking Water Standards | (CA) CALIFORNIA 2,000 ug/L /Fluoride/(DE) DELAWARE 2,000 ug/L /Fluoride ion/(PA) PENNSYLVANIA 2,000 ug/L /Fluoride ion/ |
| 州飲料水ガイドライン | (AZ) ARIZONA 4,000 ug/L /Fluoride ion/(ME) MAINE 1,680 ug/L /Fluoride ion/ |
| Federal Drinking Water Standards | EPA 4,000 ug/L /Fluoride ion/ |
| 連邦飲料水ガイドライン | EPA 2,000 ug/L /Fluoride ion/ |
| F | 10 |
| 職業暴露区分（OEB） | B |
| 職業暴露限界（OEL） | TWA: 2.5 mg/m3 [*Note: The REL also applies to other inorganic, solid fluorides (as F).] |
| 水環境危害等級（WGK） | 1 |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | WB0350000 |
| 輸送番号（UN） | UN 3415 6.1/PG III (SODIUM FLUORIDE SOLUTION) |
| 毒性 | LD50 orally in rats: 0.18 g/kg (Smyth) |
| PRTR法 | 第1種指定化学物質 |
| 税関コード | 2826 19 10 |
| 危険文句（R） | 25-32-36/38-22 |
| 化審法 | 一般化学物質 |
| 安衛法 | 57-2 |
| 危険表示 | T,Xn |
| hazard_note | Toxic/Hygroscopic |
| 安全措置（S） | 23-24/25-45-36-22 |
| 危険等級 | 6.1Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2 |
| 包装等級 | III |
| 貯蔵分類 | 6.1D - Non-combustible acute toxic Cat.3toxic hazardous materials or hazardous materials causing chronic effects |
| 有害物質データ | 7681-49-4(Hazardous Substances Data) |
用途
解説
フッ化ナトリウム，水酸化ナトリウムまたは炭酸ナトリウムをフッ化水素酸で中和すると得られる．無色の等軸晶系結晶．密度2.78 g cm－3．融点992 ℃，沸点1705 ℃．水に可溶，エタノールに難溶．水溶液はアルカリ性を示し，ガラスを侵す．フッ化水素酸に溶けてNaHF2を生じる．融剤，木材腐食の防止，殺虫剤，虫歯予防剤，発酵における消毒剤として用いられる．有毒．
用途
防腐剤，殺菌剤，殺そ剤（失効農薬）、金属表面処理剤、アルカリ中和剤、ムシ歯予防用薬剤。
用途
汎用試薬。有機合成ふっ素化剤。
用途
フラックス剤、木材防腐剤
用途
汎用試薬、調製液製造原料、有機合成用ふっ素化剤。
説明
Sodium fluoride, NaF, is a binary salt that is a clear, lustrous crystal or white powder. The insecticide grade is frequently dyed blue. It is soluble in water and has a specific gravity of 2.558, which is heavier than water. Sodium fluoride is highly toxic by ingestion and inhalation, and is also strongly irritating to tissue. The TLV is 2.5 mg/m3 of air. The four-digit UN identification number is 1690. The primary uses are fluoridation of municipal water at 1 ppm, as an insecticide, rodenticide, and fungicide, and in toothpastes and disinfectants.
一般的な説明
Sodium fluoride is a colorless crystalline solid or white powder, or the solid dissolved in a liquid. Sodium fluoride is formed by the reaction of sodium carbonate and hydrofluoric acid. Sodium fluoride is soluble in water. Sodium fluoride is noncombustible. Sodium fluoride is corrosive to aluminum. Sodium fluoride is used as an insecticide. Sodium fluoride is also used to fluorinate water supplies, as a wood preservative, in cleaning compounds, manufacture of glass, and for many other uses.
使用用途
定められた濃度（100ｍL 中 フッ化ナトリウム 0.10g 含有）に希釈したものについては、虫歯予防を目的として洗口剤や歯磨き粉などに入れることなど、さまざまな形で利用されています。用法や濃度によっては歯科医での使用に限定される場合もありますが、フッ素濃度1500ppmまでの歯磨き剤であれば市販が認められています。 他にもフッ化ナトリウムは、透明なを不透明に変化させるための乳濁剤、木材の防腐剤、アルミ合金や鉄鋼用のフラックス剤、血糖検査用の抗凝固剤などとして幅広く利用されています。
製法・合成法
製造方法
Sodium fluoride is prepared by adding sodium hydroxide or sodium carbonate to a 40% solution of hydrofluoric acid. In excess hydrofluoric acid, sodium bifluoride, NaHF2 , is formed. NaF also is made by fusion of cryolite with caustic soda. Technical grade products are usually sold at 90 to 95% purity.
調製方法
Long Yang and colleagues report a highly effective mechanochemical process to recover fluorine from PFAS as NaF, consists of ball milling PFAS with commercially available sodium silicate[1].
純化方法
Crystallise NaF from water by partial evaporation in a vacuum desiccator, or dissolve it in water, and precipitate ca half of it by adding EtOH. The precipitate is dried in an air oven at 130o for one day, and then stored in a desiccator over KOH. Its solubility in H2O is 4% at 15o and 4.3% at 25o. [Kwasnik in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 235 1963].