化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 1-Amino-7-isoquinolinol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Boron tribromide | HCID 25134 | — |
| 反応物 | 1-Isoquinolinamine, 7-methoxy- | HCID 22665644 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Amino-7-isoquinolinol | HCID 22631313 | 97.2% |
反応手順
Boron tribromide (35 mL) in 50 mL of dichloromethane was added dropwise to a stirred solution of 7-methoxy-isoquinoline-1ylamine (21.6 g) in 70 mL of dichloromethane at 10° C. After stirring for 4 d at ambient temperature the reaction mixture was poured on ice and the pH adjusted to pH 9 by adding concentrated aqueous ammonia. The precipitated material was collected by filtration and dried in vacuo to give 19.3 g (97%) of the title compound as a light brownish solid. M.p. 260° C. (decomp.); El-MS: 160 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06797710B2 |
| 出典データセット | uspto-grants-2004_09 |
| ORD ID | ord-a4b7bc23b7814a62b16420cb9d6d0711 |
| 出典メモ | uspto-grants-2004_09 |