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3-(Pyridin-2-yl)propanoic acid → N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(pyridin-2-yl)propanamide monohydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Pyridin-2-yl)propanoic acid | HCID 564292 | — |
| 反応物 | tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate | HCID 66975002 | — |
| 生成物 | N-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(pyridin-2-yl)propanamide monohydrochloride | HCID 66976608 | — |
反応手順
Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 3-(pyridin-2-yl)propanoic acid, and by a method similar to that of Example 39, the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08722662B2 |
| 出典データセット | uspto-grants-2014_05 |
| ORD ID | ord-84e4f34e7f9840ddae85facd091dd078 |
| 出典メモ | uspto-grants-2014_05 |