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HRID 10239作成日：2026年10月24日
Ethyl Acetate → 4-i-Propyl-phenyl sulfamic acid-[6-chloro-5-(o-methoxy-phenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide
https://huagongshe.com/ja/reaction/10239
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidine | HCID 11175458 | — |
| 反応物 | Sulfamide, [4-(1-methylethyl)phenyl]-(9CI) | HCID 21041219 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-i-Propyl-phenyl sulfamic acid-[6-chloro-5-(o-methoxy-phenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide | HCID 10279868 | 26.7% |
反応手順
To a solution of 4-i-propyl-phenyl sulfamic acid amide (642 mg; Referential Example 17) in DMF (9 ml) was added sodium hydride (250 mg). The mixture was warmed to 45° C. for 30 min. Then, 4,6-dichloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (1.044 g) was added and the reaction mixture was stirred for 60 h at r.t. After acidic work up and chromatography over silicagel with Hex/EtOAc=2/5, 4-i-propyl-phenyl sulfamic acid-[6-chloro-5-(o-methoxy-phenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide (0.42 g) can be isolated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07094781B2 |
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| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-44158203bde3470ebd74d37d12d5fe1d |
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| 出典メモ | uspto-grants-2006_08 |
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