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2-Dimethylamino-6-methoxyphenylboronic acid → N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Dimethylamino-6-methoxyphenylboronic acid | HCID 4374258 | — |
| 反応物 | N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester | HCID 54284267 | — |
| 生成物 | N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester | HCID 54467033 | — |
反応手順
2-Methoxy-6-(N,N-dimethylamino)benzene boronic acid was coupled with N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester to give N-(2,6-dichlorobenzoyl)-4-[2-(N,N-dimethylamino)-6-methoxyphenyl]-L-phenylalanine methyl ester. The preparation of the boronic acid and the coupling reaction was carried out in a similar manner as described in Example 7.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06521666B1 |
| 出典データセット | uspto-grants-2003_02 |
| ORD ID | ord-a72ee172b4aa48b79b24397971122fce |
| 出典メモ | uspto-grants-2003_02 |