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Benzoic acid, 3-isothiocyanato- → 3-[3-(4-Methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic acid, 3-isothiocyanato- | HCID 75046 | — |
| 反応物 | 2,2-Dimethoxy-1-methylethylamine | HCID 93658 | — |
| 反応物 | Methyl 3-(4-methyl-1H-imidazol-1-YL)benzoate | HCID 22224935 | — |
| 反応物 | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| 溶媒 | Sulfuric acid methanol | HCID 18363649 | — |
| 生成物 | 3-[3-(4-Methyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester | HCID 69592777 | — |
反応手順
Prepared from methyl 3-(4-methyl-imidazol-1-yl)-benzoate [prepared the corresponding acid from 3-isothiocyanatobenzoic acid and 2-aminopropionaldehyde dimethyl acetal according to J. Med. Chem. 1987, 30, 1342, followed by refluxing in conc. H2SO4/MeOH] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a yellow-brown oil (10.69 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06960578B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-f54b4bef9d84488786964245588baaf4 |
| 出典メモ | uspto-grants-2005_11 |