HCID 23713292、化合物 → 6-chloropyridine-2-sulfonic Acid

HRID 1074218

反応式

HRID 1074218 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([O-:11])(=[O:10])=[O:9])[N:3]=1.[Na+]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([OH:11])(=[O:10])=[O:9])[N:3]=1

参加物

3

反応物 1

HCID 23713292HCID 23713292、化合物

生成物 1

HCID 27628906-chloropyridine-2-sulfonic Acid収率 96.6%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Into 0.82 g (3.8 mmol) of sodium 2-chloropyridine-6-sulfonate prepared in accordance with Example 1, 10 ml of concentrated hydrochloric acid was added, and the mixture was stirred at room temperature overnight. Then, the solvent was distilled off, and after an addition of 200 ml of 2-propanol, the residue was heated. Insoluble matters were removed by filtration, and the filtrate was distilled under reduced pressure to obtain 710 mg (96.6%) of 2-chloropyridine-6-sulfonic acid as crystalline solid. Purification was conducted by recrystallization from 2-propanol.

後処理

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. additionafter an addition of 200 ml of 2-propanol
  4. temperaturethe residue was heated
  5. customInsoluble matters were removed by filtration
  6. distillationthe filtrate was distilled under reduced pressure

出典と根拠

ORDレコード
ord-aa9c7b4c6d564749855d4a6a05427629
出典データセット
uspto-grants-1990_11
特許番号
US04973697

関連ノート

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