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1-Hydroxybenzotriazole → N-(Morpholinocarbonyl)-L-phenylalanine S-methyl-L-cysteine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | CP 84364 | HCID 664657 | — |
| 反応物 | Methyl (2R)-2-amino-3-(methylsulfanyl)propanoate | HCID 1277655 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-(Morpholinocarbonyl)-L-phenylalanine S-methyl-L-cysteine methyl ester | HCID 67865905 | 78% |
反応手順
To a solution of 0.96 g N-(morpholinocarbonyl)-L-phenylalanine 3 and 0.55 g S-methyl-L-cysteine methyl ester in 50 mL anhydrous methylene chloride at ambient temperature was added 0.50 mL triethylamine, 0.51 g 1-hydroxybenzotriazole and 0.70 g 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride. After being stirred for 4 h, the solution was diluted with 100 mL ethyl acetate and was washed with 2×35 mL 0.1N hydrochloric acid solution and 2×35 mL 0.1N sodium hydroxide solution. The organic phase was dried over magnesium sulfate, filtered and concentrated in vacuo to afford 1.15 g of the desired solid dipeptide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05034376 |
| 出典データセット | uspto-grants-1991_07 |
| ORD ID | ord-9f93c1358bdf4432a0b26833ddc82d78 |
| 出典メモ | uspto-grants-1991_07 |