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Chloroform → 2,5-dichloro-N'-[4-(octyloxy)benzoyl]benzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,4-Dichlorobenzoyl chloride | HCID 66645 | — |
| 反応物 | 4-Octoxybenzoyl hydrazine | HCID 4281533 | — |
| 生成物 | 2,5-dichloro-N'-[4-(octyloxy)benzoyl]benzohydrazide | HCID 21982086 | — |
反応手順
Under a blanket of nitrogen, 8.8 g (0.087 mol) 2,4-dichlorobenzoyl chloride was added to a solution of 23.0 g (0.087 mol) 4-octoxybenzoyl hydrazine and 12.13 ml (8.8 g, 0.087 mol) freshly distilled triethylamine in 348 ml dry chloroform. After about one hour of stirring a dense white precipitate of the required product was formed. Stirring was continued until the next day. The product was collected by filtration and recrystallized from ethanol/water to give 31 g (81.5% yield) of 2,5-dichloro-N′-[4-(octyloxy)benzoyl]benzohydrazide as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094902B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-90306718fb4f43d4831ccc3ff610a7d0 |
| 出典メモ | uspto-grants-2006_08 |