化工社化工社 化学情報印刷レポート · 研究参考用
Benzenesulfonyl chloride → N-(3-Chloropropyl)-3,4-dimethoxy-N-methylphenethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonyl chloride | HCID 7369 | — |
| 反応物 | 3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)amino]-propanol | HCID 15283521 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3-Chloropropyl)-3,4-dimethoxy-N-methylphenethylamine | HCID 577693 | — |
反応手順
275 gm of benzenesulfonic acid chloride were added to 4 gm of 3-[N-methyl-N-(2-{3,4-dimethoxy-phenyl}-ethyl)amino]-propanol. After standing for 30 minutes, the mixture was dissolved in methylene chloride, washed with an aqueous 30% sodium hydroxide solution and water, dried over sodium sulfate and evaporated in vacuo. After purifying the residue on a silica gel column (eluant: methylene chloride/ethanol) a colorless oil was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04490369 |
| 出典データセット | uspto-grants-1984_12 |
| ORD ID | ord-ed8761a9700f43719d96aec357267180 |
| 出典メモ | uspto-grants-1984_12 |